{"id":639,"date":"2025-04-24T13:22:00","date_gmt":"2025-04-24T17:22:00","guid":{"rendered":"https:\/\/tickle.utk.edu\/bme\/?p=639"},"modified":"2025-07-28T17:02:42","modified_gmt":"2025-07-28T21:02:42","slug":"working-around-the-clot","status":"publish","type":"post","link":"https:\/\/tickle.utk.edu\/bme\/news\/working-around-the-clot\/","title":{"rendered":"Working Around the Clot"},"content":{"rendered":"\n

Good Receives AHA Award to Improve Stroke Treatment<\/h2>\n\n\n\n

One of every six deaths from cardiovascular disease in the United States is due to stroke. Of those, nearly 87% are ischemic strokes, in which a blood clot starves part of the brain of oxygen. If not treated within hours of the blockage, stroke can lead to cognitive disability, partial paralysis, and even death.<\/p>\n\n\n\n

To treat ischemic stroke, surgeons use X-rays to position clot-removal tools in the brain, but they cannot keep the X-rays on during the procedure. Instead, they must wait until the tools have been withdrawn and check by X-ray to see if blood flow was restored by the first pass (attempt). If the clot remains, surgeons reposition the tools and try again.<\/p>\n\n\n\n

\u201cEach of these passes could take 15 to 20 minutes,\u201d said Bryan Good<\/a>, an assistant professor in the Department of Mechanical, Aerospace and Biomedical Engineering (MABE) who studies the pressure, flow, and other mechanical properties of blood (hemodynamics) in diseases like ischemic stroke. \u201cAnything we can do to shave even a few minutes off a stroke treatment is critical for the patient.\u201d<\/p>\n\n\n\n

This spring, Good received a three-year, $231,000 American Heart Association (AHA) Career Development Award to create the first models of ischemic stroke that incorporate patient-accurate hemodynamics downstream of the blood clot.<\/p>\n\n\n\n

Under the mentorship of MABE Associate Professor Caleb Rucker<\/a> and Vanderbilt University Medical Center (VUMC) neurosurgeon Michael Froehler<\/a>, Good will create the world\u2019s most detailed computational model of ischemic stroke, validate the model with experimental data, and test new methods of blood clot removal.<\/p>\n\n\n\n

\u201cWe\u2019re going to be studying why some strokes are easier to treat than others,\u201d Good said. \u201cTo do that, we need accurate models of the anatomy of the brain.\u201d<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Engineering Reveals the Invisible<\/h2>\n\n\n\n

Hemodynamics is well understood in healthy brains, but measurements in stroke patients after blood clots lodge in their arteries are essentially impossible to gather. After diagnosis, surgeons are racing to save a patient\u2019s life; any unnecessary delay is out of the question.<\/p>\n\n\n\n

\u201cYou can image the brain before you treat a clot and you can image it after, but you can\u2019t see a stroke treatment in real time,\u201d Good said.<\/p>\n\n\n\n

Nonetheless, recent clinical data have shown that stroke patients with strong collateral blood flow\u2014blood flowing from other vessels to brain regions downstream of the clot\u2014have better recovery outcomes.<\/p>\n\n\n\n

Good believes understanding the role of collateral blood flow will allow clinicians to treat more ischemic stroke patients on the first pass.<\/p>\n\n\n\n

\u201cThe forces and flow mechanics happening on the other side of a blood clot have been something of a black box,\u201d Good said. \u201cAs engineers, we can build models to better understand what\u2019s happening in the brain throughout a stroke and its treatment. That\u2019s what really piqued my interest; it\u2019s where I think we can make some real improvements.\u201d<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

A Silicone Stroke Patient<\/h2>\n\n\n\n

Neurosurgeons like Froehler take computed tomography (CT) scans to diagnose ischemic stroke and evaluate patient recovery. Those CT scans can be converted into 3D models showing the real state of a patient\u2019s brain before and after treatment.<\/p>\n\n\n\n

After securing his AHA award, Good will purchase a three-foot-tall silicone model of an average ischemic stroke patient\u2019s vascular system from the heart to the brain. Good and his students will pump liquid through this model, gathering baseline data and noting how blood flows and pressures change when clots are introduced in various vessels.<\/p>\n\n\n\n

The model is made of soft silicone, so the tubes inside can flex like real blood vessels as an electronic heart \u2018pumps\u2019 the fluid through it.<\/p>\n\n\n\n

\u201cWith this model, we will really be able to understand how the collateral blood flow patterns change during a stroke and how this affects blood pressures around the clot,\u201d Good said.<\/p>\n\n\n\n

Using the experimental data from the silicone vasculature, Good and his students will build a computational model of ischemic stroke, then apply it to scans of Froehler\u2019s stroke patients from the VUMC. Eventually, the team will use their computational model to investigate new procedures and medical devices that could improve clot removal.<\/p>\n\n\n\n

\u201cWe can mimic different patient cases and investigate why one case was easier to treat than another, for example,\u201d Good said. \u201cHopefully, through this award, we\u2019re able to get a lot of good results that we can turn into larger, patient-driven studies and improve overall stroke patient outcomes.\u201d<\/p>\n\n\n\n

Contact<\/h2>\n\n\n\n

Izzie Gall (865-974-7203, egall4@utk.edu<\/a>)<\/p>\n","protected":false},"excerpt":{"rendered":"

Bryan Good received an award from the American Heart Association allowing him to create the first models of ischemic stroke incorporating clinical patient data.<\/p>\n","protected":false},"author":7,"featured_media":642,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[1],"tags":[118],"class_list":["post-639","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","tag-bryan-good"],"yoast_head":"\nWorking Around the Clot - Department of Biomedical Engineering<\/title>\n<meta name=\"description\" content=\"Bryan Good received an award from the American Heart Association, creating first models of ischemic stroke to include clinical patient data.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/tickle.utk.edu\/bme\/news\/working-around-the-clot\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Working Around the Clot - 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