{"id":627,"date":"2025-04-16T12:01:00","date_gmt":"2025-04-16T16:01:00","guid":{"rendered":"https:\/\/tickle.utk.edu\/bme\/?p=627"},"modified":"2025-07-28T17:02:42","modified_gmt":"2025-07-28T21:02:42","slug":"foundations-of-flow","status":"publish","type":"post","link":"https:\/\/tickle.utk.edu\/bme\/news\/foundations-of-flow\/","title":{"rendered":"Foundations of Flow"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Moser\u2019s Model will Help Personalize Brain SurgeryEach year, about 30,000 people in the United States experience hemorrhagic strokes, when blood from an artery suddenly bleeds into the brain. The drastic increase in pressure can damage nearby brain tissue, while disrupted blood flow starves other areas of oxygen.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">About half of hemorrhagic strokes are caused by cerebral arteriovenous malformations (AVMs), where arteries and veins connect directly. Usually, arteries and veins are separated by a network of capillaries, sites of gas exchange which allow blood pressure to decrease gently.<\/p>\n\n\n\n<figure class=\"wp-block-image alignright size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"600\" src=\"https:\/\/tickle.utk.edu\/bme\/wp-content\/uploads\/sites\/5\/2025\/07\/Mackenzie-Moser-1.jpg\" alt=\"\" class=\"wp-image-629\" srcset=\"https:\/\/tickle.utk.edu\/bme\/wp-content\/uploads\/sites\/5\/2025\/07\/Mackenzie-Moser-1.jpg 400w, https:\/\/tickle.utk.edu\/bme\/wp-content\/uploads\/sites\/5\/2025\/07\/Mackenzie-Moser-1-200x300.jpg 200w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cHigh-pressure arterial blood going into that lower-pressure vein can eventually lead to tearing of the vein,\u201d explained Mackenzie Moser, a senior in the University of Tennessee\u2019s Department of Medical, Aerospace, and Biomedical Engineering (MABE).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Though AVMs are present at birth, they are essentially undetectable until a stroke or related event occurs. Afterward, doctors can inject a liquid embolic (gelling agent) into the AVM which solidifies and redirects blood flow.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">However, since so little is known about AVMs prior to illness, the treatments are hard to personalize.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cThere\u2019s a lot we don\u2019t know about how the hemodynamic environment\u2014the internal blood pressure, temperature, and flow rate\u2014actually affects the embolic once it\u2019s solidified,\u201d said Moser.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">For the past year, Moser has been working to understand hemodynamic conditions in AVMs as a member of the UT Cardiovascular Biomechanics Lab run by Assistant Professor&nbsp;<a href=\"https:\/\/mabe.utk.edu\/people\/bryan-good\/\">Bryan Good<\/a>. She presented her research at the Society of Women Engineers 2024 conference (SWE 2024)\u2014an international gathering with thousands of attendees\u2014and won first place in the undergraduate Rapid-Fire Collegiate Competition.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This fall, she will continue her foundational research as Good\u2019s newest PhD student.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cThe fluid mechanics surrounding cerebral AVMs and their treatment options are greatly understudied,\u201d Good said. \u201cThat provides an opportunity for our lab to make significant contributions to the field, and I think Mackenzie is going to excel in graduate school.\u201dCerebral arteriovenous malformations resin model with a clamp on it.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"768\" height=\"512\" src=\"https:\/\/tickle.utk.edu\/bme\/wp-content\/uploads\/sites\/5\/2025\/07\/AVM.jpg\" alt=\"\" class=\"wp-image-630\" srcset=\"https:\/\/tickle.utk.edu\/bme\/wp-content\/uploads\/sites\/5\/2025\/07\/AVM.jpg 768w, https:\/\/tickle.utk.edu\/bme\/wp-content\/uploads\/sites\/5\/2025\/07\/AVM-300x200.jpg 300w\" sizes=\"auto, (max-width: 768px) 100vw, 768px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Early Research Opportunities<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Moser had considered going to medical school for cardiology, but the pull of engineering was too strong. She was excited to discover MABE, where the balance of math, science, and healthcare applications suited her interests perfectly\u2014and where she knew she could get hands-on experience early.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cA lot of schools said their research was saved for either seniors or graduate students,\u201d Moser recalled. \u201cDuring the engineering tour at UT, it seemed like there were a lot of research opportunities no matter what your major was.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">After working in a tissue engineering lab for two years, Moser reached out to Good in the fall of her junior year. Good quickly realized that she was the perfect fit for his newest research project\u2014so new that he had not even submitted the grant proposal yet.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cMost of the undergrads in my lab work underneath one of my PhD students on experiments related to their theses,\u201d Good said. \u201cHowever, I was looking for an undergraduate student with the right interests and motivation to develop this AVM project from scratch.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cI said, \u2018This sounds like something I would love to do, but I don\u2019t know anything about it,\u2019\u201d Moser recalled. \u201cDr. Good said, \u2018That\u2019s okay; I also don\u2019t know anything about it. We\u2019re going to figure it out together.\u2019\u201d<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"768\" height=\"512\" src=\"https:\/\/tickle.utk.edu\/bme\/wp-content\/uploads\/sites\/5\/2025\/07\/CFD.jpg\" alt=\"\" class=\"wp-image-631\" srcset=\"https:\/\/tickle.utk.edu\/bme\/wp-content\/uploads\/sites\/5\/2025\/07\/CFD.jpg 768w, https:\/\/tickle.utk.edu\/bme\/wp-content\/uploads\/sites\/5\/2025\/07\/CFD-300x200.jpg 300w\" sizes=\"auto, (max-width: 768px) 100vw, 768px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">The Groundwork of Blood Flow<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Moser began studying the flow dynamics of water through a clinically accurate resin model of an AVM in spring 2024. This January, with funding from her competitive UT Advanced Undergraduate Research Activity (AURA) grant, she started testing how the fluid dynamics in the resin model changed when she placed barriers in different areas.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As part of her doctoral thesis, Moser hopes to integrate her ongoing experimental data into a computational fluid dynamics (CFD) model that can be tweaked to emulate an individual patient\u2019s AVM\u2014and how the malformation would react to treatment.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cPhysicians would be able to input patient-specific data, simulate whichever embolic they want to use, and see what those outcomes would look like,\u201d Moser explained. \u201cIt\u2019d be a much more patient-targeted type of therapy.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Good looks forward to helping Moser continue her AVM research and expand into complementary projects in his lab, like studying the fluid dynamics of blockage removal in patients who have suffered from ischemic (clot-related) strokes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Moser\u2019s undergraduate research not only gave her the experimental basis for multiple clinically needed CFD models; it has also given her a healthy outlook on the kinds of research setbacks students don\u2019t experience in lab classes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cIt\u2019s really taught me patience,\u201d she said. \u201cIf I make a mistake, I\u2019m just going to have to learn from it. And that\u2019s okay. Trial and error are what research is all about.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contact<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Izzie Gall (865-974-7203,&nbsp;<a href=\"mailto:egall4@utk.edu\">egall4@utk.edu<\/a>)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>After graduating, Mackenzie Moser will continue her foundational research on arteriovenous malformations (AVMs), one of the leading causes of stroke, as a PhD student in Bryan Good\u2019s lab.<\/p>\n","protected":false},"author":7,"featured_media":628,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[1],"tags":[117],"class_list":["post-627","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","tag-mackenzie-moser"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Foundations of Flow - 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